Autophagy

wasted years

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#1
In 2016, Japanese biologist Yoshinori Ohsumi won the Nobel prize for medicine for his research into autophagy. Basically a physiological state the body goes into after approximately 16 hours of fasting.
The basic idea of his research is that the body will go into repair mode once starved of calories. When the body is in a Catabolic state it gets rid of the stuff it needs the least such as toxins and abnormal cells.
Better than that, the body can recycle what's good within these toxins, proteins etc and use them to hasten the repair work.
His research has proven that autophagy can slower the ageing process, improve insulin sensitivity and protect you from and fight cancer cells.
You don't win a Nobel prize for being a quack and his research is being looked into by big pharma so as they can patent a drug that mimics an authophagic state. Surely.....
Maybe Islam and Christianity were onto something with lent and Ramadan.

 

GodsDog

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#5
I try and fast at least once a year (for a few days). Came down with a fever and puked my guts out the first time I did it.

Well worth trying - fasting that is.
You aren't exactly selling this are you VG!! LOLlllllllllllll

" puked my guts up...you should try it!!" Puke

Can't wait to have a go now. You've made it sound so ... appetising!! LOLlllllllllllll
 

Mowl

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#7
As a person who eats just one meal a day and sleeps less than six hours a night and has done so since puberty, I can somewhat agree/concur with the OP's notions. From morning until night on a regular day, I get by on a coffee in the morning with a few cigarettes, and then nothing at all until night comes. One regular meal of fresh home-cooked foods which I prepare myself then feels most satisfying and prepares one for an excellent sleep.

Throughout my life I've been gently bullied by concerned family members to change, told by doctors that I'm killing myself slowly, and physiologists have told me I'm destroying my cell count and bone mass. Yet I'm rarely ill and throughout my life have managed to avoid hospitals and clinics and most types of pharmaceuticals as my health and well-being has been mostly excellent.

People look at me like I'm a freak when I describe my normal intake of nutrition per diem, they give all kinds of advice from eating porridge and drinking liters of water, cutting out the smokes and quitting the wine too. I never listen now and I've never listened before: this is what works best for me. The proof is generally to be found in the pudding, right?

Rarely been ill with common flu or cold, and if contracted, I usually beat them within twenty-four hours.
Have spent comparatively shag all on medical bills and pharmaceuticals in the course of my life.
Have spent little time in hospitals apart from in my childhood and recently for spinal surgery.
Feel in absolutely excellent physical shape with high energy levels every day.
Strong mental balanced and with positive life outlook and general sense of mood and humour.
Am just under two meters tall and slightly under my ideal BMI, but my doctors say all's well.
Recent major surgery and recovery time all on schedule with no negative side effects.
Reaction to any new medications introduced to the body are immediate and powerful.
Metabolism running at peak according recent and regular to heart/liver/blood tests.
General feeling of positive life energy high, and life expectation equally high.
The aging process has taken its time locating me, so I look twenty years younger than I actually am.
Have never been fat, have tried and failed, but I try sometimes anyway, just for the fun of it.
Full head of flowing dreads, healthy glow of Mediterranean sallow skin, sparkling dark eyes.

Most people I know who eat three or four meals a day appear unhealthy to me, prone to gaining weight, they age too fast, you can see the physical changes as they occur, they take all day to recover from a hangover for example, skin can be unhealthy, liver functions problematic as they age, skin too, not to mention hair, nails, bones, etc.

I recommend what I call the standard 'frugal diet' for a week or to and gauge for themselves the differences.

As for me, I've no need or intent to change anything: I feel in excellent health for my years and grateful for it all.

Final note: I didn't plan this lifestyle: it just happened by simple trial and error. I found that I had better energy and concentration at school if I didn't eat breakfast, so I quit it because it made me feel tired and unready for the day. A year or so later, lunch went out the window too and for the same reasons, and the result were again good with higher energy levels and peak concentration for learning etc. Not everybody has the same metabolic rate, so this doesn't and cannot work for everybody, certainly not those of an older vintage looking for a successful diet to lose weight. My only diet ever was in trying to gain weight: and I failed.

I'm glad I did too: I doubt my heart would have taken it.

But here I am: a living example of the benefits of a frugal but healthy lifestyle.
 
OP
OP
wasted years

wasted years

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#8
As a person who eats just one meal a day and sleeps less than six hours a night and has done so since puberty, I can somewhat agree/concur with the OP's notions. From morning until night on a regular day, I get by on a coffee in the morning with a few cigarettes, and then nothing at all until night comes. One regular meal of fresh home-cooked foods which I prepare myself then feels most satisfying and prepares one for an excellent sleep.

Throughout my life I've been gently bullied by concerned family members to change, told by doctors that I'm killing myself slowly, and physiologists have told me I'm destroying my cell count and bone mass. Yet I'm rarely ill and throughout my life have managed to avoid hospitals and clinics and most types of pharmaceuticals as my health and well-being has been mostly excellent.

People look at me like I'm a freak when I describe my normal intake of nutrition per diem, they give all kinds of advice from eating porridge and drinking liters of water, cutting out the smokes and quitting the wine too. I never listen now and I've never listened before: this is what works best for me. The proof is generally to be found in the pudding, right?

Rarely been ill with common flu or cold, and if contracted, I usually beat them within twenty-four hours.
Have spent comparatively shag all on medical bills and pharmaceuticals in the course of my life.
Have spent little time in hospitals apart from in my childhood and recently for spinal surgery.
Feel in absolutely excellent physical shape with high energy levels every day.
Strong mental balanced and with positive life outlook and general sense of mood and humour.
Am just under two meters tall and slightly under my ideal BMI, but my doctors say all's well.
Recent major surgery and recovery time all on schedule with no negative side effects.
Reaction to any new medications introduced to the body are immediate and powerful.
Metabolism running at peak according recent and regular to heart/liver/blood tests.
General feeling of positive life energy high, and life expectation equally high.
The aging process has taken its time locating me, so I look twenty years younger than I actually am.
Have never been fat, have tried and failed, but I try sometimes anyway, just for the fun of it.
Full head of flowing dreads, healthy glow of Mediterranean sallow skin, sparkling dark eyes.

Most people I know who eat three or four meals a day appear unhealthy to me, prone to gaining weight, they age too fast, you can see the physical changes as they occur, they take all day to recover from a hangover for example, skin can be unhealthy, liver functions problematic as they age, skin too, not to mention hair, nails, bones, etc.

I recommend what I call the standard 'frugal diet' for a week or to and gauge for themselves the differences.

As for me, I've no need or intent to change anything: I feel in excellent health for my years and grateful for it all.

Final note: I didn't plan this lifestyle: it just happened by simple trial and error. I found that I had better energy and concentration at school if I didn't eat breakfast, so I quit it because it made me feel tired and unready for the day. A year or so later, lunch went out the window too and for the same reasons, and the result were again good with higher energy levels and peak concentration for learning etc. Not everybody has the same metabolic rate, so this doesn't and cannot work for everybody, certainly not those of an older vintage looking for a successful diet to lose weight. My only diet ever was in trying to gain weight: and I failed.

I'm glad I did too: I doubt my heart would have taken it.

But here I am: a living example of the benefits of a frugal but healthy lifestyle.
Fascinating. Some on the internet have attributed the health benefits of fasting and intermitting fasting to a natural evolutionary way of eating.
Man went hunting at day and came home at night and had one big feast.
Also, our stomachs have the capacity to hold much more food than we'd get in our ordinary meal. We can actually survive without our gallbladder as it really only acted as bile pump for the big late time meals of our ancestors.
 

Mowl

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#9
Fascinating. Some on the internet have attributed the health benefits of fasting and intermitting fasting like as a natural evolutionary way of eating.
Man went hunting at day and came home st night and had one big feast.
Precisely what I repeat to my doctor whenever he/she tells me I should put on some weight.

My BMI is under and has always been under. I was born a breached blue baby who arrived seven weeks too early and spent the subsequent month in an incubation tank. Both Mother and I almost died during the delivery and sadly my time apart in incubation lead to my being disallowed breast feeding and given formula instead. I consider this to be the start of my lifestyle habits. Blue babies and their mothers tend to have difficult life relationships due to long-term psychological reactions and these can lead to further difficulties in the child's lifestyle and mental balance.

Thankfully Mother was very open about our experience and we discussed it very deeply and how she handled things herself given the problems my premature birth caused both her and me. I assume the lack of breast feeding lead to a psychological block of some sort but also one that favoured good physical and mental strength in the longer run. I feel no issues about my diet and am confident in the knowledge of how I react when I do.

Lately, and as a result of the pain-killing medications I'm using for post-spinal surgery, I tend to pass out into a deep, deep dream-filled sleep within an hour of eating: it hits like a speeding truck and I have to switch everything off and hit the hay in double-quick time. For a person living with insomniac issues, this is like diamonds from heaven.

I believe that early man lived no differently, and that modern commercialism and quack research has told us all to eat sveral times a day for no good reason. I eat when I'm hungry - not when the hands of the clock tell me to. I listen to my body, my mind, my heart: they tell me everything I need to know and I pay close attention.

It's not rocket science either: it's a simple process of elimination.
Figure out what your body needs and wants and answer only to that.
No doctor, physiologist or otherwise can tell you better than your own body can.
Learn to listen to the body, to the mind, to the heart and life energies: all the answers are already there.
 
OP
OP
wasted years

wasted years

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#10
Precisely what I repeat to my doctor whenever he/she tells me I should put on some weight.

My BMI is under and has always been under. I was born a breached blue baby who arrived seven weeks too early and spent the subsequent month in an incubation tank. Both Mother and I almost died during the delivery and sadly my time apart in incubation lead to my being disallowed breast feeding and given formula instead. I consider this to be the start of my lifestyle habits. Blue babies and their mothers tend to have difficult life relationships due to long-term psychological reactions and these can lead to further difficulties in the child's lifestyle and mental balance.

Thankfully Mother was very open about our experience and we discussed it very deeply and how she handled things herself given the problems my premature birth caused both her and me. I assume the lack of breast feeding lead to a psychological block of some sort but also one that favoured good physical and mental strength in the longer run. I feel no issues about my diet and am confident in the knowledge of how I react when I do.

Lately, and as a result of the pain-killing medications I'm using for post-spinal surgery, I tend to pass out into a deep, deep dream-filled sleep within an hour of eating: it hits like a speeding truck and I have to switch everything off and hit the hay in double-quick time. For a person living with insomniac issues, this is like diamonds from heaven.

I believe that early man lived no differently, and that modern commercialism and quack research has told us all to eat sveral times a day for no good reason. I eat when I'm hungry - not when the hands of the clock tell me to. I listen to my body, my mind, my heart: they tell me everything I need to know and I pay close attention.

It's not rocket science either: it's a simple process of elimination.
Figure out what your body needs and wants and answer only to that.
No doctor, physiologist or otherwise can tell you better than your own body can.
Learn to listen to the body, to the mind, to the heart and life energies: all the answers are already there.
So true. My grandfather used to say " eat when you're hungry and drink when you're dry" mowl, now you have a Nobel prize winning biologist backing up your theory, you can enlighten your doctors on that one
As you say, listen to your body, it's that simple.
I'm starting your diet next week and a 3 day fast before I get going just to kick start the system.
What do you have for these late night meals?
 

Mowl

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#11
So true. My grandfather used to say " eat when you're hungry and drink when you're dry" mowl, now you have a Nobel prize winning biologist backing up your theory, you can enlighten your doctors on that one(1)
As you say, listen to your body, it's that simple.
I'm starting your diet next week and a 3 day fast before I get going just to kick start the system.(2)
What do you have for these late night meals?(3)
Cheers, Bro: it's rare that anybody compliments me on my lifestyle; I'm used to constant criticism from family and medics.

Sometimes I honestly think it's simple envy that promotes this negative way of thinking. Some people react to me as though I've been given some kind of gift in this life that they haven't. To be tall and thin and healthy seems to be offensive to some, especially if you're happy and balanced with it and couldn't care less what anyone thinks.

(1) Your Grandfather would be similiar to my own: they lived a very simple and frugal life on The Rock Of Cashel during some very hard times during the last century. But both lived long lives: he until seventy-odd, and she until almost ninety with a sixty to eighty a day cigarette habit. That said, my Father died at age forty-four from lung cancer. I've smoked since I was twelve (moron that I am for even beginning) but so far my main life vice hasn't hurt me at all apart from on my chest when I overdo it.

(2) It's not a diet: it's a lifestyle - and permanent and unchangeable one.

(3) My evening meal will usually consist of two or three fresh root vegetables, some fish or poultry, a simple sauce, and no desserts. Nowadays I have no spices or herbs at all on my kitchen rack, only salt, which I only ever add for flavour after cooking. Potatoes, carrots, green beans, cauliflowers, aubergines, peppers, fresh chili, garlic, and ginger, crushed fresh tomatoes, all have flavour if cooked correctly and NOT boiled to death. I rarely eat red meat but will opt for a rare steak whenever it's going. Chicken breasts, legs, wings, are all excellent after simple broiling without sauces. I use all the juices left over from vegetable and meat/preparations to make a quick and simple sauce for food service.

I dislike sugary foods and always have: would rather snack on a fresh carrot than a Mars bar.
I discounted fresh coffee in favour of instant about five years ago: a sin to Finnish people, but hey.
I rarely drink water at all: perhaps a half liter per week of mineral water, and only when absolutely thirsty.
Never understood these people walking around with a liter or half liter of mineral water in their clutched hands.
I smoke too much in the early part of the day, particularly mornings, but come evening I don't smoke tobacco at all.
I take sauna every evening, no matter what the day has been or brought.
Mindfullness and a sense of oneness with oneself is vital to all things in life.
Monitor the body as it speaks, and don't treat it like a spoiled brat: it needs a firm slap every once in a while.

And finally, unless you're actually and medically unwell, pay no attention to what anybody but yourself has to say about what the body needs. Anybody in regular good physical/mental health knows this already. Many doctors are quacks and will try to dump meds on you that you really don't need. I consider Irish GPs to be amongst the worst at this: just walking in their door has them reaching for the prescription dockets.

Find a doctor with an open mind and open heart and talk with them: you'd be surprised which ones are smartest.
Dietologists are like hypnotists: it's all about appearance and show these days, not about wellness.
Dr Eva from Finland might be despised in a Katie Hopkins kind of way, but you know she's right.

As I said already; mine's not a diet, it's my lifestyle born of natural habit.
But I can take it anywhere in the world with me and still be sure I'm in good stead.
 
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